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I miss positioning my minions.
I've been playing hearthstone since the beta, and one of the first things that drew me into the game was how hearthstone is a cardgame where positioning matters. The first deck I fell in love with was zoo, and it's still the only deck I've played to legend. Because more than any other deck I had at the time it felt like it had so many "micro-decisions". It always felt like sequencing my plays and positioning my minions mattered or could end up mattering later in the game.
Unfortunately, positioning your minions is a game mechanic that seems to matter less and less as time goes on. Just look at this table below that contains every card where positioning matters.
Classic + Basic Every expansion so far Ancient Mage Foe Reaper 4000 Betrayal Grimestreet Protector Cone of Cold Magnataur Alpha Defender of Argus Powershot Direwolf Alpha Wee Spellstopper Explosive Shot Flametongue Totem Sunfury Defender Void Terror That just looks sad. In eight expansions we have only gotten five new cards where positioning matters. And only one of those has seen some amount of constructed play (powershot).
It doesn't help at all that we've seen some amazing positional elements in recent adventures such as "minions on the left gain charge, minions on the right gain taunt" or the auto-attacking chess pieces. Only being able to play with these mechanics against AI while I would love to play with them every game just feels like salt in the wound. (Though I wouldn't want to play with a mechanic exactly like Dorothy. We know how giving unlimited amounts of minions charge works out.)
I guess I can just say that I'm disappointed that what once seemed like a core gameplay aspect and a great way to add skill to the game without ever feeling frustrating to either player has been so terribly neglected for years.
Iksar
There are examples in the OP's post such as Argent Defender where no one gets punished for understanding how board perspective works for both players. We like minion positioning mechanics and will continue to slowly expand on them in the future. There are plenty of examples where we've sacrificed a bit on the complexity end to do something fun (Kazakus comes to mind). My comment was mostly to give some design context as to why we specifically haven't done cards like 'destroy the left most minion' and not to say that it is a bad idea we would never do.
Iksar
One of the reasons we don't do 'right' or 'left' on collectible cards is because it's actually super confusing how to play around them. Say for example 'Aim Left' (Destroy the leftmost minion) was a real card. If I was trying to play against that card, which side of the board should I place my biggest minion? My left? My opponent's left? Which way is my opponent's left? Something most people don't notice is that when you use your Shaman hero power, your totem spawns to the right. When your opponent uses their Shaman hero power, it also spawns to your right. It's as if you are viewing their side of the board from their perspective instead of your own. This is great for visual consistency, but makes doing position matters in terms of left/right quite strange.